Dr. Antonio Steardo, a pharmacologist with international training and a member of prestigious scientific societies, offers specialist consultancy in drug development and clinical data evaluation. His expertise combines pharmacokinetics, medicinal chemistry, statistical analysis, and safety review, supporting professionals and companies in need of a competent and reliable reference.
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Pharmacokinetics: absorption, distribution, metabolism, and elimination
Comprehensive analysis of ADME processes to understand how an active ingredient behaves in the body, identifying factors that influence efficacy, safety, and inter-individual variability.
Kinetics of single intravenous and oral doses
Evaluation of concentration-time profiles after a single administration, useful for defining key parameters such as clearance, volume of distribution, and absolute bioavailability.
Multiple oral dose kinetics, bioavailability, and dosage regimens
Study of accumulation, steady-state, and systemic exposure to optimize administration intervals, dosages, and formulations, ensuring a stable therapeutic profile.
The role of PK in drug development and regulatory approval
Integration of pharmacokinetic data into preclinical and clinical decision-making processes, with specific focus on regulatory requirements from EMA and FDA for marketing authorization.
In vivo/in vitro evaluations
Combined use of experimental models to predict drug behavior in humans, estimate interactions, evaluate metabolic stability, and support the selection of the< most promising molecules.
Screening and target validation strategies
Application of biochemical and cellular approaches to confirm the biological relevance of the target, reducing the risk of failure in late-stage development.
Rational drug design using protein structures
Use of molecular modeling, docking, and structural analysis techniques to guide the synthesis of compounds with optimized affinity and selectivity toward the therapeutic target.
Principles of medicinal chemistry and< drug property modulation
Optimization of physicochemical, pharmacokinetic, and pharmacodynamic properties through targeted structural modifications, improving stability, permeability, solubility, and safety profile.
Use of non-invasive imaging to evaluate clinical response
Application of techniques such as PET, MRI, and optical imaging to monitor drug distribution, biological response, and therapeutic efficacy in real-time within preclinical and clinical models.
Drug development using case studies
Analysis of real-world examples illustrating the entire development pathway, from target discovery to clinical validation, highlighting critical points, strategic decisions, and best practices.