Dr. Antonio Steardo, a pharmacologist with experience in advanced research and innovative therapies, offers specialist consultancy on major biological platforms, from gene therapy to immunotherapies. Thanks to his knowledge of molecular mechanisms, viral vectors, biomarkers, and complex clinical trial design, he supports professionals and companies in developing personalized treatments and interpreting therapeutic responses.
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Approaches to gene therapy
Overview of the main gene therapy methods, including gene transfer, genome editing, and gene expression regulation. Each approach is evaluated based on safety, efficacy, and potential clinical application.
RNA therapies
Analysis of technologies based on messenger RNA, RNA interference, and antisense oligonucleotides. These therapies allow for targeted modulation of gene expression, offering new opportunities to treat genetic, oncological, and inflammatory diseases.
Antibody-based therapies
Study of monoclonal, bispecific, and antibody-drug conjugates (ADCs). Focus on mechanisms of action, selectivity, treatment personalization, and applications in immunological and oncological pathologies.
Stem cells and immunotherapies
Evaluation of treatments based on stem cells, CAR-T, NK cells, and other cellular platforms. Analysis of immunological mechanisms, therapeutic potential, and regulatory challenges.
Cancer biology and microenvironment
Understanding the interactions between tumor cells, the immune system, and the tissue microenvironment. Fundamental for developing targeted therapies and predicting response to biological treatments.
Cancer immunology and vaccines
Study of anti-tumor immune responses and therapeutic vaccines. Includes tumor antigens, neoantigens, adjuvants, and strategies to enhance immunity against the tumor.
Viral vectors for gene therapy
Analysis of the most widely used viral vectors (AAV, lentivirus, adenovirus), evaluating efficiency, tropism, safety, and clinical applications. Essential for designing effective and safe gene therapies.
Clinical trials for vaccines and gene therapy
Design of complex clinical trials involving advanced therapies. Includes endpoint definition, safety criteria, immunological monitoring, and specific regulatory requirements for ATMPs and innovative vaccines.